Significats de discoidal high-density lipoprotein particle en anglès

Over 25 years of study have produced two general models of apoA-I structure in discoidal HDL complexes.

We show that these two different sizes of discoidal HDL particles display different stability and phospholipid-binding activity.

We report here a study of the self-assembly of discoidal HDL particles using coarse-grained (CG) molecular dynamics.

One of the major problems for high-resolution structural studies of discoidal HDL is the difficulty in obtaining pure and, foremost, homogenous sample.

In terms of discoidal HDL particles, there has been a debate as to the orientation of the apoA-I alpha-helices around the disc edge.

This application to nascent HDL validates the DSH model proposed earlier and suggests new structural details of nascent HDL.

This is consistent with lipid raft and non-raft plasma membrane domains being involved primarily in ABCA1-mediated vesicle release and nascent HDL formation, respectively.